In Episode 11 ("The Magical Place"), Skye, still searching for the kidnapped Coulson,
has the tow truck take her to the posh home of money-laundering CEO Lloyd Rathman.
When Rathman comes home, Skye poses as SHIELD agent Malinda May and
bluffs Rathman into giving her access to Vanchat's Swiss bank account.
Along the way, she also takes out two guards who arrive on the scene after
Rathman triggers a silent alarm (they wind up helping her hack the accounts).
But she gets what she came for: she finds out that Raina and Centipede recently
bought some land out in the Mojave Desert (where they're holding Coulson).
She leaves in Rathman's red Lamborghini, phones SHIELD to let them know,
and then heads out to that desert ghost town to rescue Coulson.
In the real world, this house is located at 4411 Noeline Avenue, in Encino, CA.
in L.A.'s San Fernando Valley. (It's just a few houses west of Dr. Streiten's house.)
The distinctive home has appeared in the movies before, starring in
the 2007 Anthony Hopkins / Ryan Gosling courtroom thriller "Fracture".
Here is a StreetView of the house.
[ Warning: This is a private home. Do not trespass on their property,
knock on their door, or do anything that might disturb the residents. ]