In Episode 20 ("Nothing Personal"), Skye has been captured by Ward and Deathlok,
and is being held captive aboard the S.H.I.E.L.D. team's plane ("The Bus").
In this scene, Coulson has rescued Sky, and believes he can handle Ward,
but he is unaware that the superpowered Deathlok is also aboard the plan.
When he finds out, he tells Skye to run, and they wind up sitting in Coulson's
flying red Corvette, 'Lola'. Coulson drops them out of the plane's bomb bay, but
doesn't count on 'Lola' getting shot-up during their escape. That causes the
flying car to malfunction, while they are plunging through the air to their likely deaths.
Coulson tries to start up the car, but has only limited success.
The initial sky scenes are strictly CGI/Green Screen, of course, but once they
near the ground, some very real L.A. scenery becomes visible.
ln the shot above, the car is falling past the 54-floor Ritz-Carlton Hotel tower, at the
L.A. Live complex, at 900 W. Olympic Blvd, in downtown Los Angeles.
Here is a Google StreetView of the tower.
A different view of the same skyscraper is seen below.
As Coulson regains a little control over 'Lola', the car's descent slows.
In the screenshot below, we're still at L.A. Live, but this time we're looking north/northwest
at the J.W. Marriott hotel, which is more or less part of the same glass tower complex
that houses the more expensive Ritz-Carlton.
Finally, Coulson manages a soft crash landing, where
a nonplussed valet asks him for a $20 parking fee.
This is the Nokia Plaza, at the center of L.A. Live, next to the Nokia Theatre,
across the street from the Staples Center.
(And no, there is no valet parking stand at that exact spot.)
Here is a Google StreetView of the Nokia Plaza.